"Ping An Beijing" reported on the 21st that in response to the media reports and the public’s concern about the "Park Stone Medical Laboratory", the Health and Health Department has revoked the Laboratory’s Practice License for Medical Institutions, and the market supervision department has filed a case for investigation. According to the clues of the case transferred by the Health and Health Department, the public security organ filed a case for investigation on suspicion of obstructing the prevention and treatment of infectious diseases, and took criminal compulsory measures against six people including Zhou Moumou (male, 38 years old) and Wu Moumou (male, 37 years old), the actual controller of the laboratory, and the case is under further work. For such illegal and criminal acts, the public security organs will, together with the health and market supervision departments, find out and investigate them together, and crack down severely, and will never be soft.

　 　

Previously, the website of Fangshan District Government of Beijing released a message that Beijing Pushi Medical Laboratory Co., Ltd. was revoked the Practice License of Medical Institution by Fangshan District Health and Wellness Committee because the original test data was obviously less than the number of samples tested.

　 　

The public notice of administrative punishment shows that the illegal fact is May 14, 2022. The supervisor found that the original test data of Beijing Pushi Medical Laboratory Co., Ltd. located at Room 315-323, Floor 3, Building 1, No.9 Guangyang Street, Fangshan District, Beijing was obviously less than the number of samples tested.

　 　

On May 9, Li Ang, deputy director and spokesperson of Beijing Municipal Health and Wellness Committee, informed at the press conference that during the recent flight supervision and inspection, some nucleic acid detection institutions found problems such as untimely inspection, inaccurate report and lax laboratory management, which seriously affected the quality of nucleic acid detection and the effect of epidemic prevention and control. In the list of qualified institutions audited by Covid-19 Nucleic Acid Detection Medical Laboratory in April 2022, Park Shi Medical is listed as one of the three nucleic acid institutions in Fangshan District.

　 　

In view of the existing problems, Beijing insists on problem-oriented, promptly investigates, corrects and rectifies them, and makes reforms and serious investigations, and mainly adopts four measures.

　First, according to the law and regulations, the involved nucleic acid testing institutions will be dealt with seriously. At the first time, we talked with the legal representative of the organization, demanding that in-depth inspection and analysis be carried out, and the causes of the problems should be carefully found to prevent systematic problems in quality control management; This institution is required to suspend its practice, stop undertaking the nucleic acid testing business in Covid-19, and handle it according to the law and regulations according to the further investigation. The second is to draw inferences and carry out supervision and inspection of nucleic acid testing institutions in the city. Recently, in-depth and comprehensive supervision and inspection have been carried out on nucleic acid testing institutions in the city, and a mechanism of "case must be investigated" for positive case samples has been established to find hidden dangers, plug loopholes, adhere to problem orientation, comprehensively sort out problems, and prevent similar incidents from happening. The third is to strengthen cooperation and form a joint force of safety and quality supervision. Strengthen industry management and communication and coordination, establish a joint supervision mechanism for nucleic acid inspection quality in conjunction with drug administration, public security and other departments, carry out the "bright sword" special governance action, further strengthen the quality supervision of Covid-19 nucleic acid testing laboratory, improve the workflow, and strengthen the process audit; Establish a regular supervision mechanism, conduct regular spot checks on personnel samples in key industries, conduct regular spot checks and cross-checks on samples submitted by key industries such as express delivery services, circulation management services and hotel services, and conduct regular special inspections and quality and safety spot checks on testing institutions. The fourth is to trace the whole process and establish a reward and punishment mechanism for quality evaluation. The whole process of suspicious cases and positive samples detection should be traced back, and the institutions with standardized nucleic acid detection and strict quality control should be notified and praised, and the task of nucleic acid detection should be tilted.Institutions whose nucleic acid detection quality does not meet the standard shall be investigated and dealt with in informed criticism according to the law and regulations.　

Li Ang said that the quality of nucleic acid detection is related to the overall situation of epidemic prevention and control. We will always adhere to the people first and life first, strictly control the quality of nucleic acid detection, strictly observe the bottom line of epidemic prevention work, and make every effort to protect people’s health and life safety.

　　We all have to breathe, but what kind of breathing method is good for our health, have you ever thought about it? Learn the correct breathing methods, what methods does Chinese medicine have?

　　How can I learn to breathe correctly?

　　There are two key points. First, it is necessary to ease the inhalation, that is, when inhaling, it should be even and slow, and try to inhale deeply so that the gas can fill the alveoli. The second is to vomit hard and clean, so that all the waste can be discharged from the body and more gas can be exchanged. The most scientific breathing method is: "Breathe-stop (hold your breath for 10-20 seconds)-breathe", which can enhance the excitability of parasympathetic nerves and increase the number of bowel sounds, which is beneficial to digestion and absorption, thus benefiting health and longevity.

　　Another advocated breathing method is the "total breathing method" based on deep and long abdominal breathing, which gradually makes the muscle groups such as lungs, ribs and diaphragm move to the maximum extent when breathing, so that the air fills the lungs. Although you have to practice deliberately at first, the ultimate goal is to integrate into life, and all kinds of postures and movements are combined with breathing. This will better grasp the strength and rhythm of the body and improve efficiency. For example, when climbing a mountain by breathing, there will be no mountain symptoms such as headache; You can swing farther in golf. This breathing method can be practiced on the bus, when walking, during work, or in front of the trees in the park. Especially in the face of sudden negative situations, breathing can adjust body and mind and stabilize emotions in a timely manner.

　　In the fresh air outdoors, you can also take more deep breaths consciously. The specific method of breathing is to inhale slowly through the nostrils. During the inhalation, the chest is lifted, and the abdomen will bulge slowly, and then continue to inhale, so that the whole lung will be filled with air. At this time, the ribs will be lifted and the chest will be enlarged. This process usually takes 5-10 seconds, then hold your breath for 5-10 seconds, pause for 2-3 seconds, and start a new breath. Repeated practice will become a correct breathing method.

　　Long-term physical exercise can also improve breathing. For example, swimming can make people’s vital capacity as high as 5000-7000 ml; Far greater than the average person’s 3000-4000 ml; Long-distance running has the most obvious improvement on the maximum oxygen uptake; Push-ups can improve the muscle ability around the chest wall and increase the strength of respiratory muscles.

　　Chinese medicine teaches you to learn abdominal breathing.

　　"Breathing to the navel, longevity and harmony with the sky" is a high evaluation of abdominal breathing by health care experts. Ancient Chinese doctors have long recognized that abdominal breathing has the wonderful function of eliminating diseases and prolonging life, and created fitness methods such as "breathing", "turtle breathing", "qi sinking into the abdomen" and "fetal breathing". Sun Simiao, a famous doctor in the Tang Dynasty, especially praised abdominal deep breathing. He practiced the method of regulating qi every day between dawn and noon, lying on his back in bed. In the Ming Dynasty, Leng Qian, a health care expert, wrote a 16-character health care order in "Essentials of Aging": "When you inhale, you will lift it, and the qi will return to your navel; When you mention it, you will swallow, and you will meet with fire and water. " These 16-character secrets include three health-care training methods: lifting anus, swallowing body fluid and abdominal breathing, which are magic weapons for eliminating diseases, keeping fit and prolonging life.

　　Traditional Chinese medicine believes that the abdomen lives in the middle of the human body and is the place where many important meridians converge. Abdominal breathing, with the ups and downs of abdominal muscles, strengthens the operation of qi and blood, makes the human body in the best state of relaxation and freedom, and is also the best state of menstrual flow, which is very beneficial to physical and mental health.

　　Abdominal breathing method:

　　Inhale deeply, consciously feel that the whole chest and abdomen are full when inhaling, then exhale slowly, and try to spit out the air in your body when exhaling, feeling that your chest and abdomen are flat. Inhale with your nose and exhale with your mouth.

　　When doing abdominal breathing, you can stand, sit and lie down, and you can practice it anytime and anywhere, but lying in bed is the best way to practice. Lie on your back in bed, loosen your belt, relax your limbs, concentrate your thoughts and get rid of other thoughts. Put your right hand on your belly button and your left hand on your chest. When inhaling, expand the abdomen outward to the maximum extent and keep the chest still. When exhaling, contract the abdomen inward as much as possible and keep the chest still. Cycle back and forth, keep the rhythm of each breath consistent, and carefully experience the ups and downs of the abdomen together.

　　The specific exercise method is: supine, according to 5 ~ 6 times per minute, the abdominal wall bulges when inhaling through the nose, and sinks when exhaling through the mouth. Abdominal breathing exercises should vary from person to person, according to one’s ability. The key is to do one’s best in the range of abdominal depression when inhaling and exhaling, but we should not rush into it. We should start from shallow to deep, and exercise at our own discretion every time and every day. Generally, we should practice once every morning and evening for 10 minutes.

　　For people in good health, the breath holding time can be appropriately extended, and the breathing rhythm should be slowed down and deepened as much as possible. People who are in poor health can not hold their breath, but they should absorb enough gas. If body fluid overflows during breathing, it can be swallowed slowly.

　　Principles when doing abdominal breathing

　　First, breathe deeply, long and slowly.

　　Second, breathe through your nose instead of your mouth.

　　Third, breathe in and breathe in for about 15 seconds, that is, breathe in deeply (bulge your stomach) for 3-5 seconds, hold your breath for 1 second, then exhale slowly (retract your stomach) for 3-5 seconds, hold your breath for 1 second.

　　Fourth, do it for 5 ~ 15 minutes at a time, and 30 minutes is the best.

　　Fifth, people who are in good health can hold their breath for a longer time and try to slow down and deepen their breathing rhythm; If you are in poor health, you don’t have to hold your breath, but you should inhale enough and exhale thoroughly.

　　Practice 1 ~ 2 times a day, and you can choose sitting, horizontal, walking and running. Practice until it is slightly hot and sweaty, and try to bulge and retract the abdomen for 50 ~ 100 times. You can also help with your hands. If there is overflow of oral fluid during breathing, do not spit it out, but swallow it slowly.

　　Method for relieve dyspnea by massage

　　1. Touch your chest. Keep underwear, lie on your back, relax all over, press your palms against your breasts, put your fingers together, and touch your chest with your fingers. At the same time, your right hand rotates 50 times to the right and your left hand rotates 50 times to the left. Then rotate 50 times in the opposite direction. Note: This section can relieve chest tightness, angina pectoris, asthma and shortness of breath. However, if you don’t get better, even persistent chest symptoms such as crushing pain and dyspnea behind the sternum may be acute myocardial infarction for more than 30 minutes. Go to a big hospital for rescue.

　　2, palms overlap massage chest and abdomen. With the abdomen between the two breasts as the center, the palms overlap. First, put the right hand under it and rotate it clockwise for 50 turns, then change the left hand under it and rotate it counterclockwise for 50 turns. Repeat, push out and pull in, gradually expand the scope, and the action should be slow and powerful.

　　3. Take a deep breath and massage your chest and abdomen with your palms crossed. Press on the right flank with the palm of your right hand, and press on the left flank with the left palm. At the same time, lift and rub (Dabao, Qimen, Tianchi, Xiongxiang, Zhou Rong, etc.) with both hands to the chest (inhale deeply at the same time), and push the palms alternately, with the right hand pushing up (Zhongfu, Yunmen, Yufu, Xuanji, etc.) and the left hand pushing down (fake window). When inhaling, let the chest expand as much as possible and bulge slowly; When exhaling, make the chest as narrow as possible and the abdominal muscles contract. (Hold your breath for a moment) Breathe through the nose repeatedly for 1 minute. Inhale oxygen and exhale carbon dioxide, enhance vital capacity and improve heart and lung function.

　　4, alternating hands, patting the chest and rubbing the back. When sitting or standing, first slap the left chest with the palm of your right hand, and at the same time beat the left back with the backhand of your left arm, and then beat the back (body column, Feishu, Xinshu, etc.) for 1 minute with alternating hands.

　　However, what needs to be pointed out here is that massage is only a "technique" and a "method"; The "Tao" is not angry, emotional stability and so on.

　　Learn the above breathing methods to benefit your body more.

　

CCTV News:According to WeChat official account, Beijing Center for Disease Control and Prevention, Japan announced that it would start discharging nuclear polluted water from Fukushima into the sea on the afternoon of August 24th, which caused global concern and heated discussion. Many citizens in Beijing also started to snap up edible salt. Some citizens think that "iodized salt can prevent nuclear radiation", which is incorrect. Many citizens want to know whether iodized salt can prevent the accumulation of radioactive iodine in the thyroid gland, so as to protect the thyroid gland.

The purpose of iodizing salt in China is to prevent and treat iodine deficiency disorders. Because Beijing is an iodine-deficient area in the environment, iodization with salt can supplement iodine nutrition for the whole people safely, conveniently and for a long time, so as to avoid iodine deficiency affecting the health of residents. According to China’s "National Food Safety Standard Iodine Content of Edible Salt", the iodine content in iodized salt is 20-30mg per kilogram. In a nuclear pollution accident, radioactive iodine is mainly accumulated in the thyroid gland. In the early stage of the accident, it is necessary to take 100mg of "stable iodine" once, which is equivalent to taking 3-5kg of edible iodized salt once. The Dietary Guidelines for China Residents (2022) clearly states that "adults should not consume more than 5g of salt every day". If excessive intake occurs, it will cause serious burden to various organs of the human body, induce or aggravate cardiovascular and cerebrovascular diseases and chronic nephropathy, and even cause dehydration and even death in severe cases.

Therefore, it is not advisable to prevent nuclear radiation by eating iodized salt!

　　The report on the implementation of monetary policy in China in the first quarter of 2023 issued by the People’s Bank of China said that there is no deflation in China’s economy at present, and there is no basis for long-term deflation or inflation in the medium and long term.

　　According to data recently released by the National Bureau of Statistics, in April 2023, the national consumer price (CPI) rose by 0.1% year-on-year and decreased by 0.1% quarter-on-quarter; The national producer price (PPI) decreased by 3.6% year-on-year and 0.5% quarter-on-quarter. The year-on-year increase of CPI continued to fall, hitting a new low in April since March 2021. How to treat the current domestic price situation correctly? What will be the next price trend?

　　Affected by many factors, prices are falling.

　　Careful consumers will find that with the blooming of spring, vegetables and fruits on the market are not only more abundant, but also more and more "close to the people", and the latest statistics also reflect this change. In April, a large number of fresh vegetables and fresh fruits were put on the market, and the prices dropped by 6.1% and 0.7% respectively. The production capacity of live pigs is sufficient, and the price of pork decreased by 3.8% due to the influence of off-season consumption.

　　Dong Lijuan, chief statistician of the Urban Department of the National Bureau of Statistics, said that in April, the market supply was generally sufficient, and consumer demand gradually recovered. The core CPI excluding food and energy prices changed from flat last month to 0.1%, up 0.7% year-on-year, and the increase was the same as last month.

　　Dong Lijuan analyzed that from the ring comparison, in April, the travel demand increased during the small holiday, and the transportation rental fees, air tickets, hotel accommodation and tourism prices all rose, with the increase rate ranging from 4.6% to 8.1%; Affected by the fluctuation of international crude oil prices, domestic gasoline and diesel prices both fell by 1.7%; Merchants cut prices to promote sales, and the prices of fuel cars, new energy cars and household appliances dropped by 1%, 0.9% and 0.6% respectively.

　　Zhang Xuewu, director of the Analysis and Forecast Division of the Price Monitoring Center of the National Development and Reform Commission, said that fresh vegetables, gasoline and diesel, and fuel cars together affected the CPI by about 0.9 percentage points, which was the main reason for the low CPI operation. In April, PPI decreased by 0.5% month-on-month and 3.6% year-on-year. Zhang Xuewu believes that due to the international tension last year, the central banks of cardinal utility, the United States and Europe continued to raise interest rates, which led to the slowdown of economic growth and the financial risk spillover of some major developed economies. The international commodity price volatility was weak and had an import impact on China.

　　Xiong Yuan, chief economist of Guosheng Securities, believes that the recent decline in China’s prices is due to various factors such as the decline in pork prices, the slow recovery of service prices, and the weakening of commodity prices.

　　Zhang Xuewu said that the current downward trend of prices is mainly caused by the disturbance of high base, which is staged and temporary, and should be treated objectively and rationally and analyzed comprehensively and accurately. On the one hand, due to the influence of import, seasonal factors and high cardinal utility, the prices of some commodities have fallen more, which is the main reason for the current CPI decline; Affected by international geopolitics and other input factors, PPI has declined, but these factors are temporary. On the other hand, at present, China’s demand has recovered rapidly, and the overall economy has rebounded. In the first quarter, China’s GDP increased by 4.5%, and the growth rate was 1.6 percentage points faster than that in the fourth quarter of last year. This year’s "May 1" holiday tourism consumption recovery momentum is very strong.

　　China’s economy has not experienced deflation.

　　Prices are closely related to people’s lives. Low prices mean less living expenses, which can reduce the pressure of life. However, the relatively low price movement has also caused some people’s concern. Is deflation coming?

　　The report of the People’s Bank of China clearly indicates that there is no deflation in China’s economy at present. Deflation mainly refers to the continuous negative growth of prices and the downward trend of money supply, which is usually accompanied by economic recession. China’s prices are still rising moderately, especially the core CPI is stable at about 0.7% year-on-year, M2 and social finance are growing relatively fast, and the economic operation continues to improve, which is not in line with the characteristics of deflation. In the medium and long term, China’s total economic supply and demand are basically balanced, monetary conditions are reasonable and moderate, residents’ expectations are stable, and there is no basis for long-term deflation or inflation.

　　Wang Yuanhong, deputy director of the Economic Forecasting Department of the National Information Center, said that at present, the overall price level in China has not yet declined generally and continuously, so there has not been deflation.

　　Zhong Zhengsheng, chief economist of Ping An Securities, said that China’s GDP deflator rose in the first quarter compared with the fourth quarter of last year, which confirmed that deflation is a false proposition. The GDP deflator is not only a weighted average of CPI and PPI, but also a more comprehensive and comprehensive indicator. The highlight of China’s economy in the first quarter was the tertiary industry, which was fully reflected in the GDP deflator.

　　Wang Jinbin, deputy dean of the School of Economics of Renmin University of China, believes that China’s economic development situation determines that deflation is impossible. China’s economic output gap is narrowing, which determines that there will be no deflation. Estimates of China’s potential economic growth rate are mostly in the range of 5.0%~6.0%, while the GDP growth rate in the first quarter is 4.5%, and the output gap is converging. Although the PMI index was below the critical point of 50 in April, the production index was 50.2%, which continued to be above the critical point, indicating that manufacturing production maintained expansion.

　　Guan Tao, global chief economist of Bank of China Securities, said that at present, China’s CPI and core CPI inflation levels are low, but there has not been a continuous decline in the overall price level and the money supply, and there has not been a negative economic growth, which does not meet the definition of deflation. Low inflation is only because China’s economy is in a recovery period, and the anti-inflation force is strong, and the force to promote price recovery is gradually accumulating strength. Although the recent year-on-year decline in China’s PPI reflects the fall of commodity prices in cardinal utility and the world, it does not conform to the definition of deflation.

　　Moderate price level provides space for expanding demand.

　　How long will the current price decline last? What will be the trend of price operation throughout the year? How to expand domestic demand and stabilize growth in the next step?

　　The report of the People’s Bank of China predicts that CPI will fluctuate within a narrow range at a low level in the coming months due to the influence of a high base. From May to July this year, CPI will remain low in stages, mainly due to the high base of CPI increase of about 2.5% in the same period last year. With the reduction of the base, especially the policy effect, the gap between supply and demand is expected to close. It is expected that the CPI center may rise moderately in the second half of the year and may rise to near the average level in recent years at the end of the year.

　　Guo Liyan, director of the Comprehensive Situation Office of China Macroeconomic Research Institute, said that the analysis of prices should not only look at the "shape" of the month, but also comprehensively look at the "potential" of the quarter and the year. In April, the overall domestic price level was in a reasonable range, and the relatively low operation was only a seasonal and temporary phenomenon, not a trend feature. At present, China’s economy has a solid foundation of "stability" and a strong momentum of "progress". The endogenous kinetic energy is constantly increasing, and the supply and demand sides are recovering towards equilibrium. In particular, the consumption of contact services has rebounded significantly, which has led to an increase in employment and income, and the upward trend of the economy will gradually show up in prices. Looking forward to the whole year, the overall domestic price level will fluctuate slightly and moderately within a reasonable range.

　　According to Wang Yuanhong, after calculation, the low point of CPI and PPI increase in the year is in the second quarter. With the gradual recovery of the economy and the weakening of cardinal utility, the CPI and PPI increase will gradually increase in the third and fourth quarters, and the annual price may show a "V-shaped" trend.

　　Zhong Zhengsheng believes that the economic recovery is reflected in the price breakdown data, but the kinetic energy of household consumption growth needs to be further consolidated, and the current price level can create a better environment for further efforts to stabilize the growth policy.

　　Guan Tao believes that it is necessary to combine the implementation of the strategy of expanding domestic demand with deepening the supply-side structural reform, giving play to the effectiveness of policies and stimulating the vitality of business entities.

　　Wang Yuanhong suggested that in the next step, we should continue to implement a proactive fiscal policy and a prudent monetary policy, maintain macro-policy control, strengthen coordination and cooperation of various policies, and give priority to restoring and expanding consumption. Through government investment and policy incentives, we will effectively promote the investment of the whole society, give play to the supporting role of exports in the economy, and promote the overall improvement of economic operation.

　　Wang Jinbin said that the core of China’s high-quality economic development is innovation. A moderate price level can avoid excessive investment, and resources will be concentrated in long-term innovation areas. The moderate price level also provides space for the macro-policy of expanding demand. He suggested that a number of policies should be introduced to boost consumer confidence, focusing on supporting the consumption of end products with long industrial chains, and supporting local governments to introduce policies to expand household consumption and enhance residents’ sense of acquisition and happiness, so as to further consolidate the important role of consumption in steady growth. (China Development and Reform Newspaper reporter Tian Xinyuan)

　　Cctv newsAccording to the website of the People’s Bank of China, at the end of September, the balance of broad money (M2) was 165.57 trillion yuan, up 9.2% year-on-year, and the growth rate was 0.3 percentage points higher than the end of last month and 2.3 percentage points lower than the same period of last year. The balance of narrow money (M1) was 51.79 trillion yuan, up 14% year-on-year, and the growth rate was the same as the end of last month, 10.7 percentage points lower than the same period of last year. The balance of money in circulation (M0) was 6.97 trillion yuan, a year-on-year increase of 7.2%. In the first three quarters, the net cash input was 144.5 billion yuan.

　　In the first three quarters, RMB loans increased by 11.16 trillion yuan and foreign currency loans increased by 30.5 billion US dollars.

　　At the end of September, the balance of local and foreign currency loans was 123.18 trillion yuan, a year-on-year increase of 12.5%. At the end of the month, the balance of RMB loans was 117.76 trillion yuan, up 13.1% year-on-year. The growth rate was 0.1 percentage point lower than that at the end of last month and 0.1 percentage point higher than that at the same period of last year.

　　In the first three quarters, RMB loans increased by 11.16 trillion yuan, a year-on-year increase of 998 billion yuan. In terms of sectors, loans to households increased by 5.73 trillion yuan, of which short-term loans increased by 1.53 trillion yuan and medium-and long-term loans increased by 4.2 trillion yuan; Loans from non-financial enterprises and government organizations increased by 5.73 trillion yuan, of which short-term loans increased by 1.72 trillion yuan, medium-and long-term loans increased by 5.51 trillion yuan, and bill financing decreased by 1.72 trillion yuan; Loans from non-banking financial institutions decreased by 296.3 billion yuan. In September, RMB loans increased by 1.27 trillion yuan, a year-on-year increase of 56.6 billion yuan.

　　At the end of September, the balance of foreign currency loans was US$ 816.3 billion, a year-on-year increase of 1.5%. In the first three quarters, foreign currency loans increased by $30.5 billion, an increase of $56.4 billion year-on-year. In September, foreign currency loans decreased by $16.4 billion, a year-on-year decrease of $11.2 billion.

　　In the first three quarters, RMB deposits increased by 11.68 trillion yuan and foreign currency deposits increased by 61.5 billion US dollars.

　　At the end of September, the balance of local and foreign currency deposits was 167.42 trillion yuan, a year-on-year increase of 9.5%. At the end of the month, the balance of RMB deposits was 162.28 trillion yuan, up 9.3% year-on-year. The growth rate was 0.3 percentage points higher than the end of last month and 1.8 percentage points lower than the same period of last year.

　　In the first three quarters, RMB deposits increased by 11.68 trillion yuan, a year-on-year decrease of 1.13 trillion yuan. Among them, household deposits increased by 4.48 trillion yuan, non-financial enterprises increased by 2.03 trillion yuan, fiscal deposits increased by 789.2 billion yuan, and non-banking financial institutions increased by 1.24 trillion yuan. In September, RMB deposits increased by 433.2 billion yuan, a year-on-year increase of 433.8 billion yuan.

　　At the end of September, the balance of foreign currency deposits was US$ 774.5 billion, a year-on-year increase of 16.4%. In the first three quarters, foreign currency deposits increased by $61.5 billion, an increase of $23.7 billion year-on-year. In September, foreign currency deposits decreased by $13.1 billion, a year-on-year decrease of $30.7 billion.

　　In September, the monthly weighted average interest rate of interbank lending in RMB market was 2.92%, and the monthly weighted average interest rate of pledged bond repurchase was 3.07%.

　　In the first three quarters, the inter-bank RMB market traded a total of 580.12 trillion yuan by means of borrowing, cash coupons and repurchase, with an average daily turnover of 3.07 trillion yuan, which decreased by 8.5% compared with the same period of last year. Among them, the average daily turnover of interbank lending decreased by 22.9% year-on-year, the average daily turnover of cash bonds decreased by 21.6% year-on-year, and the average daily turnover of pledged repo decreased by 2.2% year-on-year.

　　The weighted average interest rate of interbank lending in September was 2.92%, which was 0.05 percentage points lower than last month and 0.67 percentage points higher than the same period of last year. The weighted average interest rate of pledged repo was 3.07%, 0.02 percentage points lower than last month and 0.79 percentage points higher than the same period of last year.

　　The balance of China’s foreign exchange reserves is 3.11 trillion US dollars.

　　At the end of September, the balance of China’s foreign exchange reserves was $3.11 trillion. At the end of September, the RMB exchange rate was 6.6369 yuan to 1 US dollar.

　　In the first three quarters, RMB settlement of cross-border trade amounted to 3.23 trillion yuan, and RMB settlement of direct investment amounted to 962.3 billion yuan.

　　In the first three quarters of 2017, cross-border trade in goods, trade in services and other current accounts, foreign direct investment and foreign direct investment settled in RMB amounted to 2.41 trillion yuan, 823 billion yuan, 246.9 billion yuan and 715.4 billion yuan respectively.

　　Note 1: Current data are preliminary.

　　Note 2: Since October 2011, the money supply has included deposits from the housing provident fund center and deposits from non-deposit financial institutions in deposit financial institutions.

　　Note 3: Since August 2014, entrepot trade has been adjusted to goods trade for statistics, and the amount of goods trade has expanded, while the amount of service trade has decreased accordingly.

　　Note 4: Since 2015, RMB, foreign currency and local and foreign currency deposits include deposits from non-banking financial institutions, while RMB, foreign currency and local and foreign currency loans include loans to non-banking financial institutions.

　　Study cartoon schematic diagram. Photo courtesy of respondents

　　There are problems such as drug resistance and drug toxicity, and it is impossible to completely reverse the damaged bone — — There are still some defects in the conventional anti-bone resorption drugs and bone anabolic drugs that have been used at present. For the elderly with declining organ function, it is difficult to bear the whole course of treatment, which restricts the overall effect of conventional anti-osteoporosis treatment.

　　On the eve of the World Osteoporosis Day on October 20th, Professor Fan Shunwu, Director of Orthopedics of sir run run shaw hospital, and the research team of Professor Tang Ruikang from the Department of Chemistry of Zhejiang University published a research result in the international authoritative magazine JACS. Through a new nano-material, baking soda (sodium bicarbonate) can be adsorbed on the bone surface in a targeted way, which can inhibit osteoclasts and fundamentally prevent osteoporosis. The team proved that it can inhibit the bone destruction of osteoclasts safely and intelligently through the in vivo experiments of mouse osteoporosis model.

　　The "termite disease" that eats bones needs to be cured urgently.

　　Osteoporosis is a kind of senile bone disease with decreased bone density and bone quality due to various reasons. With the acceleration of social aging in China, its incidence rate is getting higher and higher. In 2018, National Health Commission released the epidemiological survey of osteoporosis in China for the first time. The results show that China is 40-mdash; The prevalence rate of osteoporosis in 49-year-old population is 3.2%, that in 50-year-old population is 19.2%, and that in 65-year-old population is 32%. The bone health problems of middle-aged and elderly people in China are serious, and the population with low bone mass is huge, especially women.

　　"Young people should also pay attention to early prevention. Unhealthy lifestyles such as unbalanced diet, long-term meditation, smoking and drinking, and too little sunshine will affect the accumulation of basic bone mass, and bone mass is more likely to be lost after entering middle-aged and elderly people. " Lin Xianfeng, the first author of the above research paper and the attending physician of the Department of Orthopaedics, Run Run Shaw Hospital of Zhejiang University, said that it is conservatively estimated that the population of osteoporosis in China is close to 90 million.

　　According to the existing research, the primary cause of osteoporosis is the abnormal activation of osteoclasts, and the "acid" secreted by osteoclasts is considered to be the key initial factor of osteoclasts’ bone destruction and a necessary prerequisite for their degradation of bone tissue.

　　"If human bones are compared to a big tree, then osteoclasts are termites in the big tree. Once the activities of termites become active for various reasons, even the towering trees will collapse due to long-term decay." Fan Shunwu explained.

　　At present, the main drugs for the treatment of osteoporosis in clinic can achieve the purpose of anti-bone absorption and promoting bone synthesis and metabolism by focusing on the biological regulation of osteoclasts or osteoblasts, which can slow down the loss of bone mass in the elderly to a certain extent, but there is no key initial step of killing the external acid environment formed by osteoclasts from the source.

　　"Therefore, the existing drugs cannot completely reverse the bone destruction that has occurred, and non-bone selective administration will also lead to off-target and other organ toxic side effects." Fan Shunwu said that this series of problems has led to the poor clinical treatment effect of osteoporosis.

　　After acid and alkali neutralization, it is made into "biological armor"

　　Amazingly, baking soda reacts with acid, consuming hydrogen ions and producing carbon dioxide — — The "acid-base neutralization reaction" that people can learn in middle school has been unlocked by the research team.

　　According to reports, although osteoclasts are the source of osteoporosis, many studies show that they can promote bone formation and blood vessel formation as "precursor cells" before acid secretion, so it is very important to accurately target and inhibit osteoclasts.

　　Based on the basic chemical principle of acid-base neutralization, the research team has packed nontoxic and harmless baking soda (sodium bicarbonate) into a safe nanocapsule (liposome), and loaded tetracycline with bone binding force on the surface to enable it to be targeted and adsorbed on the bone surface. When osteoclasts secrete acid to destroy bone tissue, they will immediately release sodium bicarbonate, inhibit the function of osteoclasts, and achieve the goal of fundamentally preventing osteoporosis.

　　Tang Ruikang explained that, generally speaking, after the baking soda alkaline liposome material enters the body, it will form an alkaline "biological armor" for the bone and maintain the acid-base balance of the local microenvironment of the bone.

　　Lin Xianfeng introduced that this armor is more like the "soft armor" in martial arts novels. It has no interference with ordinary cells, but it has intelligent and long-term defense effects on cells that actively attack bone tissue like osteoclasts.

　　Studies have fully confirmed that sodium bicarbonate liposome material can completely prevent osteoclasts of osteoporosis mice from secreting acidic substances and dissolving bones in animals, and it has been confirmed by a series of observation methods such as micro-CT that it can preventively prevent the loss of bone mass, so that the bone mass can be preserved to a nearly normal and healthy level.

　　"We also confirmed the safety of this study on non-acid-secreting cells (osteoblasts, chondrocytes, mesenchymal stem cells, etc.) in the main organs and bone tissues of mice." Lin Xianfeng said.

　　"The new intelligent material used in the research is not a scarce object. The key synthetic raw materials it uses, such as sodium bicarbonate, liposomes and tetracycline, are all safe substances that have been widely used in clinic for a long time." Fan Shunwu believes that this is a favorable condition for the results to be put into clinical application.

　　"This study has opened up a new idea for the treatment of osteoporosis with new nano-drugs through its precise and intelligent effect on osteoclasts." Lin Xianfeng said that on the whole, this study shows a good prospect of clinical transformation and follows the treatment concept of "from biology" that we have always admired.

　　[car home Professional Evaluation] In the past two years, Honda and Toyota have been doing the same thing, that is, putting another car between their compact and medium-sized SUV models. The prices of these cars are cheaper than their big brother, but the workmanship configuration has surpassed that of the compact younger brother. Once these cars came out, they were basically well received and sold well. Toyota’s Lingfang is one of them. Today, I brought the test report of the flagship version of FAW Toyota-Lingfang HARRIER 2022 dual-engine 2.5L CVT four-wheel drive, which is the top model of the whole department with a guide price of 297,800 yuan.

●　Comfort evaluation

　　Lingfang’s seat is wide and thick, which is more comfortable to sit on. The inner padding of the seat cushion and backrest is soft and has no support or wrapping, but it is very comfortable to sit on. The front functional area is clear, and there is a physical air conditioning control area, so it is convenient to adjust the temperature and air volume.

　　The experiencer is 180cm, weighs 62kg, and the front seat is adjusted to the lowest position and the appropriate sitting posture. The front head space is left with one punch, and the front row remains unchanged and comes to the back row. The head space is left with four fingers, and the leg space is left with one punch and four fingers. The performance is not bad.

　　The storage space in the Lingfang car is quite satisfactory. The only small problem is that the size of the storage slot in the front row is a little small, and after putting the mobile phone, almost everything else can’t fit.

　　The size of the trunk of Lingfang is similar to that of Rongfang. After all, the wheelbase is almost the same. It is worth mentioning that the height of the trunk from the ground has reached 800mm, so it must be a bit laborious to carry large items.

　　Lingfang HARRIER 2022 dual-engine 2.5L CVT Four-wheel Drive Flagship Edition performs fairly well. As the top model of the whole system, all comfort configurations such as front/rear parking radar, panoramic image, reversing car side warning system, electric/inductive trunk, keyless entry, adaptive far and near lights, automatic air conditioning, front seat heating/ventilation, steering wheel heating, JBL stereo and so on are fully equipped.

　　Lingfang’s center console and door elbow are all wrapped in leather fabric, and the steering wheel and seat are all made of leather, which feels delicate. Overall, the materials used in the car are very good, which is much better than RAV4 Rongfang.

　　The configuration of the front seats is very high, the ventilation and heating are all complete, the comfort of the seats is also good, and the length of the seat cushion is in place for supporting the legs; However, the comfort of the rear seats is average, the sitting height is low, the length of the seat cushion is not enough, and the leg support is not good. Secondly, the configuration is not high, only the air conditioning outlet is provided, and there is no temperature and air volume adjustment system.

　　Lingfang’s noise test performance is remarkable. If it is not a strong power request, the driver and passenger can hardly hear the noise of the engine. During daily driving, the tire noise can still be heard obviously in the car. If the speed rises, the wind noise will be a little big, but the final measured data is ok, and the results at low and medium speeds are lower than the recommended values.

●　Dynamic evaluation

More exciting videos are all on the car home video platform.

　　In the acceleration test, the acceleration momentum of Lingfang was very strong at the moment when the brake was released. With good torque release and the blessing of the four-wheel drive system, there was no slippage in the initial stage, and the acceleration momentum in the middle and later stages remained very good. The 2.5L hybrid system did not disappoint, and the final acceleration score of 0-100km/h was 7.75 seconds.

　　The smoothness of the E-CVT gearbox is very good, and the vehicle power is very linear. In addition to the normal mode, Toyota also provides this car with ECO and SPORT modes. In the sports mode, the dynamic response of this car will be more intense, and the basic speed will be higher. Compared with the ordinary and ECO modes, we can still feel obvious differences. There is a small detail that I like very much. I like the feeling of the accelerator pedal very much. Its damping spring is very strong, so it won’t be very tired when driving in traffic jams. You can take advantage of the pedal.

　　Although Lingfang is a domestic SUV, the configuration of the power part of the top version is not low, and the hardware of motor+four-wheel drive is placed here, so its dynamic response speed and the force in the middle and rear sections are online, overtaking and merging within the legal speed limit is effortless, and the acceleration of 40-80km/h is better, which takes 3.78 seconds, and the performance of 80-120km/h is even more outstanding, which takes only 5.38 seconds.

　　Lingfang’s steering feel is heavy, and there are some empty positions in the middle, and the reaction and directivity of the front of the car are also somewhat blurred, but fortunately, the steering wheel will be slightly lighter at low speed, and parking will not be too laborious. On the whole, if the steering force is lighter, it may be more comfortable to drive every day.

　　Although Lingfang’s throttle responds quickly and accelerates smoothly, there will be no torque steering and suspension feeling when starting the car with full strength.

　　The suspension is still the calibration of the domestic SUV. The initial stage is relatively soft, and it filters well the fine bumps on the road surface, but its middle and rear stages are still relatively hard. In the past few days of testing, when I passed a relatively large ditch or speed bump, its suspension was not sloppy, and bang bang passed twice, which was very simple.

　　The overall texture of the chassis is very good, and the overall feeling is very strong. Its level is indeed higher than RAV4, and there is not much vibration introduced into the car. When passing through a large area or deep potholes, the car does not have abnormal sound or loose feeling, and the overall feeling is in line with the level that this price should have.

More exciting videos are all on the car home video platform.

　　Like RAV4, the 2.5L hybrid version of Lingfang uses the E-Four four-wheel drive system. This set of electric four-wheel drive has a general ability to get rid of difficulties, and its horsepower and torque are also insufficient. First, the test of double front wheels and double rear wheels, Lingfang’s performance is not good enough, which is a little more laborious than many four-wheel drive models we tested, but it finally passed. Followed by the test of the cross axle, the vehicle did not hesitate too much, and the wheels did not slip obviously, and passed smoothly. It did not perform well in the test of single front wheel and single rear wheel. After a series of outputs, it could not get out of trouble, and the speed of limiting slip was a little slow and the strength was not enough, which failed the challenge.

　　The approach angle and departure angle of Lingfang are both 24 degrees, the bottom ground clearance is 19cm, the minimum ground clearance is 19cm, and the turning diameter is 11.75m m..

　　　The following is the test of cross-country field. First, it is a 36-degree slope. Compared with its eldest brother Lu Fang, Ling Fang’s performance in this project is good. Although the process is a little laborious, he finally succeeded in climbing to the top. The reason is that it is light in weight, and the pressure on the rear of the vehicle with a weight of 1760kg will be much less. However, the 42-degree slope is still the same. After the angle becomes larger, the lower rear wheel torque and grip are not enough for the vehicle to climb the slope, and the challenge fails.

　　The test performance of the roll slope is good, and there is no obvious sliding phenomenon at the front and rear of the car, and the direction can pass smoothly without too much correction. In the Butterfly Valley test, Lingfang performed well, and the vehicle did not support the bottom in the process of uphill. It was easier to do cross-axis movements at the top of the slope, and the challenge was successful.

　　In the continuous cannonball pit project, there was an obvious bottoming phenomenon in Lingfang, and it was ok when passing through the first steamed bun bag, but the vehicle was directly supported on the steamed bun bag at the second cannonball pit position, and the challenge failed.

More exciting videos are all on the car home video platform.

　　Lingfang is not equipped with functions such as off-road mode and steep slope descent. Generally speaking, Lingfang’s four-wheel drive system and body size setting are more for highway four-wheel drive and bad roads. It will be more difficult to use it for some moderate off-road projects.

●　Safety evaluation

More exciting videos are all on the car home video platform.

　　Ling Fang’s performance in the brake test is not satisfactory. First, the vehicle’s posture is not good when fully braking, and the vehicle leans forward obviously. Second, the grip of the four tires is not very good, but the braking force is released evenly, the braking G value fluctuates unobvious, and the foot feel is also very good. This is reflected in this generation of Highlander, and the final braking distance of the vehicle at 100-0km/h is 40.62 meters.

　　Except for the steering damping, the overall handling of Lingfang is poor. When Zone A enters Zone B, the suspension support is very general, the car body has a large roll, the tire grip is not good, and the front of the car responds slowly when changing lanes urgently, so the driver needs to adapt for many times before finding the best turning opportunity. After entering Zone B, the intervention of electronic stability control system is not strong enough, which leads to the speed of Zone B entering Zone C is still too fast, and the braking process will be accompanied by the harsh sound of hub motor, and the highest passing speed is only 68.2 km/h.

More exciting videos are all on the car home video platform.

　　Lingfang has a moderate sitting posture in the front row, a good view, and a good view of the external rearview mirror. The internal rearview mirror is a streaming media rearview mirror, which has a good visual range and clarity, and it will be safer to drive at night.

　　The passive safety configuration of Lingfang is very comprehensive. The whole system comes standard with front airbags, front side airbags, front and rear head air curtains and knee airbags. It feels good to treat them equally.

●　Economic evaluation

　　The car we actually measured is the top model of Lingfang, with a guide price of 297,800 yuan. Generally speaking, it is still a little expensive, but at present, this car should have a discount of about 21,000-25,000 yuan, so the final landing price is ok. If you think it is still expensive, it is enough to buy a luxury version or a premium version, and the configuration can also meet the needs of home use.

　　　This fuel consumption test runs 104.5km, with an average speed of 31 km/h. Under this working condition, we test between congestion, urban roads and expressways, and start the ECO mode and engine start-stop function all the time. Because it is a summer test, the air conditioner is turned on all the time, and the actual filling of No.92 gasoline is 5.92L, and the measured fuel consumption is 5.7L/100km.

●　Intelligent evaluation

　　Similarly, the active safety configuration of Lingfang is also very complete. The whole system comes standard with a full-speed adaptive cruise system, including parallel line assistance, lane departure warning, lane keeping assistance system and lane keeping function. I like it.

　　Compared with the central control panels of most Toyota models I have tested before, Lingfang’s car system has indeed made great progress. First of all, the shape, including the thickness of the frame, is relatively thin. Second, its sensitivity and clarity are also online. In addition, the intelligence of the car machine is also very good. In addition to providing basic functions such as online navigation and online music, it also provides functions such as hotel reservation, online video, hotel reservation and take-away reservation.

●　Full text summary:

　　Lingfang’s performance in the performance test is not very good. Besides good acceleration performance, poor tire grip affects the performance of braking and elk test. If a set of tires with better performance can be replaced, the final test result will definitely be better. Off-road is also its weak part. The weak rear wheel power and general limited slip ability can’t help this car get out of trouble. But its advantage is actually not here. Urban roads are its home. It is actually very comfortable to drive every day. The power is very good, the noise of the engine is not very big, and the fuel consumption is still very low. Coupled with sufficient comfort and active and passive safety configuration, this car is definitely qualified as a home SUV.

　　Regarding the market of this car, I also visited several 4S shops and inquired about the current preferential price of Lingfang. Some of them gave the following policies: the fuel version discount is 15,000 yuan, the hybrid discount is 20,000 yuan, the installment car purchase rate is 0 for 2 years, the down payment is 60%, the installment car purchase discount is 23,000 yuan, the white car needs to be increased by 2,000 yuan, the vehicle is given a basic maintenance of 100,000 kilometers for 4 years, and the adhesive pad is all negotiable, but there is a 4S shop. (Photo/Text/Photo by car home Xie Wei)

●　Comfort evaluation

　　The two main points are deducted. First, the information such as the average speed and subtotal time on the dashboard and the central control panel will be automatically erased after each restart of the vehicle, which is not conducive to the driver’s statistics of daily fuel consumption performance. I deducted points at the dashboard scoring point. Secondly, the tire noise is high at low speed, and the engine noise is high at high speed, and the subjective noise perception part is also deducted.

●　Dynamic evaluation

　　There are several main penalty points in this part. First, in terms of steering and driving stability, Lingfang’s steering feel is not accurate and heavy, and its controllability in the elk test and the performance of the vehicle when shifting its center of gravity are not very good. Secondly, the performance of cross-country venues is not good, except for the objective passing or not, the subjective experience is not very good, and points are deducted in these projects.

●　Safety evaluation

　　In this part, the performance of Lingfang is high and low, and the low part is that the performance of the brakes is really bad. Besides the actual performance, the subjective feeling is not good, but the car is very good in vision and the number of airbags, and the scores are all higher than the average score of the same level.

●　Economic evaluation

　　The total score of Lingfang in the economic evaluation part is 9.42, and the main reason for the high score is its fuel consumption performance. The measured fuel consumption per 100 kilometers is only 5.7L/100km.

●　Intelligent evaluation

　　The intelligent part got a score of 19.20, which was better than that of competitors of the same level, especially the active safety part, which was fully equipped and could fully meet the daily use requirements.

●　Total score of AH-100

On March 11th, the tank brand held the first owners’ meeting, and the tank officially released the user brand "TANK LIFE". At the meeting, various tank brand modified models were unveiled. At the same time, the tank official announced that it will build a tank 300 3.0T model based on the limited edition of the tank 300 border, and the estimated price is around 300,000.

In addition, tank brands are based on models such as Tank 300 and Tank 500, and will continue to extend more derivative models through the forms of user co-creation and unbounded co-creation with brand owners. Of course, the first model to be introduced is the tank 300 3.0T+9AT model.

According to the official of the tank brand, "Tank Life" combustion life includes three parts: products, channels and services, which realizes the interaction in nine fields, such as personality upgrading, camping, climbing and photography, and forms a global ecological co-creation platform.

In terms of product co-creation, tanks will carry out vehicle co-creation, expand modification culture and share modification results. At the same time, it will also build a "tank brand experience base", where users will be invited to experience new products, including professional off-road projects such as climbing, wading and cannonball pits. On the level of service experience, the official will promote the tank academy, light up the earth plan, and tank good things.

The brand-new tank 300 model will be sold in the form of crowdfunding, with 1000 copies of crowdfunding, each with 20,000 yuan, and each user can only buy one copy. If the project successfully reaches the crowdfunding goal, the project will be started in April. According to the project development scope, it is expected that the project development will be completed in the second quarter of 2024, and successful users will become product partners, and they will enjoy five special rights and interests, such as early adopter rights, co-creation rights, expansion rights, shining rights and harvest rights.

In addition, it is reported that the tank brand will enter more overseas markets, and it has been explored in Saudi Arabia, Iraq and Australia. The tank official announced that in 2023, the tank will continue to promote the market processes such as ASEAN and accelerate its layout into the European market with strict access standards. In the future, tanks will enter more global markets. At that time, tanks will also simultaneously promote the "Lighting the Earth Plan" for overseas self-driving. In addition, Tanks expects to set up 30 overseas clubs this year, covering Southeast Asia, the Middle East, Australia, Russia and other regions.

Since the 18th National Congress of the Communist Party of China, China’s intangible cultural heritage protection has gone through a remarkable and crucial five-year development process. Cultural administrative departments at all levels thoroughly implemented the spirit of a series of important speeches by the Supreme Leader General Secretary on the inheritance and development of Chinese excellent traditional culture, implemented the relevant requirements of the Opinions on Implementing the Inheritance and Development Project of Chinese Excellent Traditional Culture issued by the Central Office and the State Council, and actively promoted the protection and inheritance of intangible cultural heritage in accordance with the People’s Republic of China (PRC) Intangible Cultural Heritage Law (hereinafter referred to as the "Intangible Cultural Heritage Law"), promoted the creative transformation and innovative development of Chinese excellent traditional culture, and continuously enhanced the vitality and influence of intangible cultural heritage, with remarkable results.

Deepen the concept of protection and consolidate the achievements of protection

In the past five years, the protection of intangible cultural heritage has taken a big step from the basic work stage of "rescue and protection, establishing rules and regulations" to the deep development stage of "consolidating the achievements of rescue and protection and improving the level of protection and inheritance".

Since Kunqu Opera was selected as UNESCO’s "representative work of oral and intangible heritage of mankind" in 2001, the government-led protection of intangible heritage in China has gone through 16 years. For more than 10 years, under the great attention of the CPC Central Committee and the State Council, and through the joint efforts of cultural administrative departments at all levels and all walks of life, China’s intangible cultural heritage protection has made remarkable achievements. From 2005 to 2009, China launched the first large-scale nationwide intangible cultural heritage survey, and the total number of intangible cultural heritage resources was nearly 870,000, which comprehensively understood and mastered the types, quantity, distribution, survival and inheritance of intangible cultural heritage resources in various regions and ethnic groups. On this basis, China has established a national, provincial, municipal and county-level intangible cultural heritage list system. Up to now, the State Council has approved the publication of four batches of 1372 national representative projects, and all provinces, autonomous regions and municipalities have approved the publication of 13087 provincial representative projects. The Ministry of Culture named four batches of 1986 national representative inheritors, and 14928 provincial representative inheritors were named by provinces, autonomous regions and municipalities. In order to strengthen the overall regional protection of intangible cultural heritage and its breeding and development environment, since the establishment of the Minnan Cultural and Ecological Protection Experimental Zone in 2007, China has successively set up 21 national-level cultural and ecological protection experimental zones (hereinafter referred to as "ecological zones") in areas where intangible cultural heritage projects are concentrated, distinctive features and contents and forms remain intact, and strived to promote each ecological zone to become an area with rich heritage, strong atmosphere, distinctive features and benefits for the people.

With the formal promulgation and implementation of the Intangible Heritage Law in 2011, the legal system and working mechanism of intangible heritage protection in China are becoming more and more perfect. Twenty-six provinces, autonomous regions and municipalities across the country have promulgated regulations on the protection of intangible cultural heritage; The state has set up a special fund for the protection of intangible cultural heritage; Non-legacy offices and non-legacy protection centers have been established in various places. From the rescue and protection to the establishment of regulations, many "China experiences" have been recognized by the international community in the practice of intangible cultural heritage protection for more than 10 years.

In the past five years, the Ministry of Culture has continuously improved the top-level design and standardized the work flow, and the working mechanism focusing on protecting the inheritance practice, ability and environment has been continuously improved, and the specific work has been carried out in a more in-depth and detailed manner. For example, the system norms on the protection and management of non-legacy representative projects, the identification and management of representative inheritors, the management of special funds, and the construction and management of cultural and ecological protection zones have been further improved; Actively explore the establishment of performance evaluation system for key projects, key work and non-legacy protection projects; Study and formulate protection, inheritance and revitalization plans in different categories.

The concept of intangible cultural heritage protection has also been deepened. In recent years, the Ministry of Culture has emphasized three concepts: first, the concept of protection in improvement. The key to intangible cultural heritage protection is inheritance. Only by constantly improving the level of inheritance can we enhance the expressive force and attractiveness of intangible heritage, maintain and expand the space for its survival and development, encourage and attract more people to join the ranks of inheritance, and realize sustainable intangible heritage protection. The second is the idea of non-legacy entering modern life. Intangible heritage is the cultural imprint of a nation and the way of life of a nation and a region. Intangible Cultural Heritage is the practice of live transmission with people as the core and life as the carrier. Non-legacy lives in life, and it is necessary to promote non-legacy to be more fully integrated into contemporary people’s lives on the basis of adhering to tradition and not losing its roots, so that non-legacy can be passed down in the daily lives of thousands of families. The third is the ecological protection concept of seeing people, things and life. In the process of ecological zone construction and traditional village protection with the Ministry of Housing and Urban-Rural Development, the Ministry of Culture requires that intangible cultural heritage projects be protected together with the humanistic environment that they have nurtured and nourished; It is required to preserve the aborigines in the transformation of ancient villages and old streets, protect the lifestyle of aborigines, avoid traditional villages and old streets becoming hollow sites with only buildings and shops without aborigines, and avoid inheriting the environment and soil without loss.

The level of protection and inheritance has jumped to a new level.

Improving the development level of non-genetic inheritance is an important way and an inevitable choice to strengthen cultural self-confidence and build a strong cultural country.

In the past five years, the central government has invested a total of 4.6 billion yuan in intangible cultural heritage protection, and the central budget has allocated 1.1 billion yuan to build 153 intangible cultural heritage protection and utilization facilities, and the subsidy for national representative inheritors has been increased from 10,000 yuan to 20,000 yuan per year. The local finance has invested a total of 3.9 billion yuan. Except for Heilongjiang and Jilin, all provinces, autonomous regions and municipalities have set up a subsidy ranging from 3,000 yuan to 20,000 yuan for the representative inheritors at this level. A large number of representative projects have been effectively protected and the vitality of inheritance has been greatly improved; The inheritance conditions of representative inheritors have been significantly improved, and their social status has been continuously improved.

In the past five years, the Ministry of Culture has fully realized that in the current historical background, we must strive to maintain the conditions for the continuation of intangible heritage, and at the same time take correctly responding to environmental changes and realizing the sustainable development of intangible heritage as the priority direction of policy research and formulation, and take improving the ability of inheritance and practice as the top priority.

After in-depth research, in 2015, the Ministry of Culture, together with the Ministry of Education, launched a training program for non-genetic inheritors in China to provide academic and teaching resources support for non-genetic inheritors. Up to now, 78 colleges and universities across the country have held more than 280 training courses, and with extended training, a total of more than 40 thousand people have been trained. Through the practice of research and training, non-genetic inheritors and practitioners not only have increased their knowledge, broadened their horizons and improved their skills, but also have a deeper understanding of the cultural connotation of their projects and a stronger confidence in the value and potential of their own skills. Moreover, they have promoted the interaction between universities and communities, which is of great significance for enriching academic accumulation, improving the level of discipline and professional construction, strengthening the education of excellent traditional culture, and enhancing the ability of cultural inheritance and innovation.

Since 2016, according to the requirements of the Fifth Plenary Session of the 18th CPC Central Committee and the Outline of the 13th Five-Year Plan for National Economic and Social Development, the Ministry of Culture has taken the lead in researching and formulating the China Traditional Craft Revitalization Plan. In March this year, the General Office of the State Council forwarded this plan. In the process of drafting the plan, the Ministry of Culture actively explored effective measures to revitalize traditional crafts, supported relevant enterprises, colleges and institutions to set up traditional craft workstations in Hami, Xinjiang, Xiangxi, Hunan, Leishan, Guizhou, Guoluo, Qinghai, Huangshan, Shanxi, Xinzhou and Dongyang, Zhejiang, and helped local traditional craft enterprises and practitioners to restore and promote excellent crafts, explore national elements and develop rich national and regional characteristics on the basis of respecting local culture, national traditions and craftsmen. At present, enterprises stationed in Hami, Xiangxi and Leishan Workstations have developed hundreds of new products using local ethnic elements together with local craftsmen. The increase in orders has led to an increase in the income of craftsmen, and the inheritance team of traditional crafts in these places has expanded, and young people have begun to join. Some traditional skills projects have been revived by increasing income and expanding employment.

Constructing the record of cultural ecological development

The construction of cultural and ecological protection zone is a regional overall protection mode to adapt to the rheological and holistic characteristics of intangible cultural heritage. Paying attention to holistic protection is one of the distinctive features of the "China experience" of intangible cultural heritage protection. Up to now, 21 ecological zones have been announced, involving 17 provinces and regions such as Fujian, Anhui, Jiangxi, Qinghai and Sichuan. Referring to the concept and practice of ecological zones, provinces, autonomous regions and municipalities have also set up 146 provincial-level cultural and ecological protection zones with distinctive features.

In the past five years, in order to further clarify the direction and path of ecological zone construction, the Ministry of Culture has put forward the working concept of "seeing people, seeing things and seeing life" and the construction goal of building an ecological zone with rich heritage, strong atmosphere, distinctive features and benefiting the people.

The Ministry of Culture emphasizes that in the construction of ecological zone, we should focus on highlighting the main position of non-genetic inheritors and local residents, highlighting the bearing role of communities, paying attention to atmosphere construction, enhancing people’s sense of acquisition and cultivating unique characteristics. The main body responsible for the construction of ecological zone is the local government, the community where the intangible cultural heritage project is located and the people who inherit it. Local governments should take the initiative to assume the responsibility and obligation of protection. They should not only report the construction situation to the Ministry of Culture, but also regularly solicit opinions from all walks of life in the region, conduct self-evaluation and third-party evaluation, and announce the evaluation results to the public.

In the past five years, the Ministry of Culture has continuously strengthened its guidance on the work of ecological areas. On the one hand, it has guided the ecological areas to make a good overall plan, requiring each ecological area to identify its own characteristics and form its own characteristics, on the other hand, it has taken targeted support measures. Up to now, the overall planning of 16 of the 21 ecological zones has passed the demonstration and approval, and is being implemented; The master plans of two ecological zones are being compiled, and the master plans of three ecological zones are being compiled.

From 2011 to 2015, the Ministry of Culture supported the construction of 151 non-legacy comprehensive learning centers through the central finance; In 2016, the central government allocated 23.9 million yuan to support the construction and operation of 62 non-genetic learning centers in 18 national ecological zones, and arranged 25.2 million yuan to add 287 non-genetic learning points in ecological zones; In 2017, we will continue to support the ecological zone to carry out overall protection and universal education.

The work of intangible cultural heritage records is also a basic work for the protection of intangible cultural heritage. Since the 18th National Congress of the Communist Party of China, the Ministry of Culture has carried out the intangible cultural heritage records on the basis of previous investigation records, and gradually summed up the experience and expanded and established the intangible cultural heritage records project.

In order to effectively promote the rescue record work, since 2013, the Ministry of Culture has selected 50 representative inheritors across the country to carry out rescue record pilot projects, and started to organize the drafting and formulation of relevant business standards and technical specifications, which provided a scientific basis for comprehensive roll-out. In April, 2015, the Ministry of Culture issued the Notice on Carrying out the Rescue Recording Work of Representative Inheritors of National Intangible Cultural Heritage, and started the recording work of 300 national representative inheritors who are over 70 years old and under 70 years old but are sickly, and implemented it step by step year, so as to fully complete the rescue recording work of national representative inheritors during the Thirteenth Five-Year Plan period. Up to now, the central government has supported 839 national representative inheritors to carry out rescue records, and the unique skills and cultural memories carried by a group of representative inheritors have been recorded and preserved.

On the basis of the rescue records of national representative inheritors, the Ministry of Culture listed the intangible record project in the "Cultural Development and Reform Plan of the Ministry of Culture during the Thirteenth Five-Year Plan", and made a comprehensive, true and systematic record of the content, expression, evolution process, core skills and inheritance practice of intangible representative projects. At present, the Ministry of Culture is studying and formulating the overall plan of the intangible recording project, and determining the recording content, implementation steps, achievement forms, performance evaluation and sustainable mechanism of the intangible recording project.

Open up the pattern of modern non-genetic broadcasting

General Secretary of the Supreme Leader pointed out that it is necessary to make the most basic cultural genes of the Chinese nation adapt to contemporary culture and coordinate with modern society, spread them in a way that people like to see and hear and have extensive participation, carry forward the cultural spirit that spans time and space, spans the country, is full of eternal charm and has contemporary value, and spread the cultural innovation achievements of contemporary China that inherit excellent traditional culture and carry forward the spirit of the times, and is based on its own country and faces the world.

Over the past five years, as a representative of Chinese excellent traditional culture, Intangible Cultural Heritage has emerged in various international major events and conferences, and has become a beautiful business card for spreading Chinese culture. Various types of non-legacy exhibitions and live experience booths are often regarded as the "leading" cultural activities in international cultural exchange activities, and the wonderful non-legacy performances are full of praise from the representatives of various countries who come to the conference. In the process of Chinese culture going abroad, non-legacy also plays an important role. In overseas China Cultural Center, Tai Chi and calligraphy training are popular, and China traditional festivals and folk activities are widely spread.

In China, during the Spring Festival, Dragon Boat Festival and other traditional festivals and the "Cultural and Natural Heritage Day", a variety of non-legacy publicity and exhibition activities have comprehensively demonstrated the outstanding practical achievements of the party’s non-legacy protection work since the 18th National Congress, creating an atmosphere for the whole society to inherit and develop excellent traditional culture. According to statistics, in the past five years, 320,000 exhibitions of intangible cultural heritage have been held nationwide, with 540 million people participating. China Chengdu International Intangible Cultural Heritage Festival has been held for 6 times in 10 consecutive years, and China Intangible Cultural Heritage Expo has been held for 4 times in 8 consecutive years, with a variety of exhibitions, academic discussions and skill competitions, showing the intangible vitality and creativity. Extensive non-legacy community activities have improved the people’s sense of identity and participation in the protection of non-legacy and enhanced the motivation of inheritance practice. During the "Cultural and Natural Heritage Day" this year, the "splendid china-China Intangible Cultural Heritage Dress Show" held in Beijing Gongwangfu Museum attracted extensive media attention and reports. According to public opinion, in such non-genetic broadcasting activities of spinning, dyeing, weaving and embroidery with China characteristics and China style, it is very likely that the national brand with national characteristics will be stepped out and become a powerful leader in revitalizing China’s traditional crafts.

In recent years, the Ministry of Culture has attached great importance to exploring and constructing a normalized and professional non-genetic broadcasting system. At the end of August this year, the Department of Intangible Cultural Heritage of the Ministry of Culture and the Network News and Information Communication Bureau of the Central Network Information Office held an advanced seminar on non-genetic broadcasting, aiming at cultivating professional non-genetic broadcasting teams and promoting multi-level and multi-channel dissemination of intangible cultural heritage protection. A few days ago, a large-scale network communication activity of intangible cultural heritage, which was sponsored by the Ministry of Culture and the Central Network Information Office, was held in full swing. More than 200 media representatives from nearly 100 central news websites, local news websites and commercial websites went to Guizhou, Fujian, Shanxi and Hubei respectively. Through on-the-spot interviews and personal experiences, they reported in depth the vivid practice of non-genetic inheritance and development, and stimulated the vitality and vitality of Chinese excellent traditional culture with diversified means of communication. A vivid situation of inheriting and developing excellent traditional culture for all is taking shape. (Reporter Wang Xuesi)

China is a "big country", with more than 140 million diabetics, among whom about 72.83 million diabetics have not been diagnosed. Because diabetes requires lifelong medication, there is a huge demand for diabetes drugs in the market.

According to the Rong Yun database, the hospital sales of diabetes drugs (chemical drugs/biological drugs) in China increased from 20 billion yuan in 2014 to 34.3 billion yuan in 2021, with a compound annual growth rate of 7.99%.

Hospital sales of diabetes drugs market

Screenshot Source: Drug Rong Yun National Hospital Sales Database

The market of diabetes drugs is 0.13 billion yuan, and the head effect is obvious.

Diabetes mellitus is a metabolic disease characterized by hyperglycemia in clinic, but the etiology and pathogenesis have not been fully understood at present. Its therapeutic drugs can be divided into two categories: non-insulin hypoglycemic agents and insulin hypoglycemic agents, and subdivided into ten categories: biguanides, insulin and its analogues, GLP-1 receptor agonists, sulfonylureas, glinides and GKA drugs. Jost Sullivan report shows that the current antidiabetic drug market in China is mainly occupied by traditional drugs, and half of it is occupied by insulin.

According to the statistics of Rong Yun Drug Database, among the TOP10 varieties in the hospital sales of diabetes drugs in 2021, except Dapagliflozin tablets, sitagliptin phosphate tablets and liraglutide injection, the other seven varieties are all insulin and its analogues.

Insulin aspart 30 injection and insulin glargine injection topped the list with sales exceeding 3 billion yuan.

TOP10 varieties of in-hospital sales of diabetes drugs market in 2021

Source: Rong Yun National Hospital Sales Database.

The new diabetes drugs listed in 2022 are remarkable.

Compared with 2021, Hengrui Pharma’s Henggliclazide, Microchip’s Sigliclazide, Tanabe Mitsubishi Pharmaceutical’s Tegliclazide and many other new drugs were approved in China one after another. This year, fewer new diabetes drugs were approved, but all of them were remarkable and very eye-catching.

Hualing Medicine:Dogleetin tablets

On October 8, dorzagliatin, the first in class hypoglycemic agent of Hualing Medicine, was officially approved by NMPA for listing, with the trade name of Huatangning. Two indications of Huatangning were approved at one time, namely, using metformin alone to treat patients with type 2 diabetes who have not been treated with drugs, and using metformin alone in combination with metformin to treat adults with type 2 diabetes when blood sugar control is not good.

This is the world’s first approved GKA,Glucokinase Activator (GKA), the first original new drug with a brand-new mechanism in the field of diabetes in the past decade, and the first new drug for type 2 diabetes in the world launched in China for the first time. As a GKA drug, Dogleetin can restore the blood glucose homeostasis of patients with type 2 diabetes by restoring the function of glucose kinase (GK), and achieve the purpose of treating type 2 diabetes.

Lilly:Tirzepatide; tirzepatide

In May, 2022, FDA approved the listing of tirzepatide (trade name: Mounjaro), a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide -1(GLP-1) receptor from Lilly. This drug is the first GLP-1R dual-target hypoglycemic drug for treating type 2 diabetes, and it is only injected once a week to assist diet and exercise, so as to improve the blood sugar control of adults with type 2 diabetes.

Research and development status of tirzepatide

Screenshot Source: Drug Rong Yun Global Drug R&D Database

In China, Lilly submitted the IND application for Telpotide Injection for the first time in April 2019, and started clinical trials in August of the same year. So far, a number of phase III clinical trials for type 2 diabetes, heart failure and obesity have been carried out; In September this year, Lilly officially submitted the marketing application of the new diabetes drug to CDE.

Tirzepatide clinical trial information (search "Medicine Rong Yun applet" for more relevant data query)

Screenshot Source: Drug Rong Yun China Clinical Trial Database

The research and development market of diabetes drugs has intensified, pending the inventory of new drugs by listed stars.

Under the policy of normalization of quantity procurement and consistency evaluation, the competition in the domestic diabetes generic drug market is gradually becoming fierce, and at the same time, it also forces domestic enterprises to move from generic drugs to Fast-follow and First-in-class.

The research and development of pharmaceutical companies has been accelerated, and many pharmaceutical companies have gathered together hot targets to compete for involution. At present, a number of new diabetes drugs have entered the phase III clinical stage, and some products have submitted listing applications in China.　

Newly declared new diabetes drugs in China

Up to now, in addition to the telpotide mentioned above, there are several new diabetes drugs that have been submitted for marketing in the domestic diabetes drug market, which are worthy of attention.

Sihuan medicine:Jiaglinide tablets

On February 28th, the application for the listing of Jiagelijing tablets, a new drug of Sihuan Medicine, was accepted by CDE. This is a glucose sodium cotransporter 2(SGLT-2) inhibitor independently developed by Sihuan Medicine for the treatment of diabetes, which has been patented in China, the United States, Europe, Japan and South Korea for the treatment of type 2 diabetes. If approved for marketing, it will become the second SGLT-2 inhibitor drug independently developed by China after Hengrui Proline Hengglinide Tablets.

Novo Nordisk:Smegliptide tablets

On May 27th, Novo Nordisk’s application for the listing of Smegliptide Tablets was accepted by CDE. Smegliptide is a GLP-1 receptor agonist. Its injection has been approved for marketing in China, and its tablet has been approved for blood sugar control in adults with type 2 diabetes overseas, making it the first oral GLP-1 receptor agonist (GLP-1RA) in the world. According to the Rong Yun database, two phase III clinical trials of Smegliptide tablets compared with placebo or sitagliptin in the treatment of patients with type 2 diabetes have been completed. It is speculated that the declared indication is to treat type 2 diabetes.

Clinical trials of smeagoutide tablets in China

Screenshot Source: Drug Rong Yun China Clinical Trial Database

Hengrui Pharma:Repagliptin phosphate tablets

Repagliptin phosphate tablets in Hengrui Pharma, a DPP-4 inhibitor with similar structure to sitagliptin on the market, are also suitable for type 2 diabetes. It was submitted to the market in September 2020 and accepted. Proline Henggliclazide tablets reported at the same time were approved for marketing on the first day at the end of 2021, becoming the first SGLT-2 diabetes drug independently developed in China. Whether repaglinide can be approved before the end of 2022 is of concern.

Studying new drugs for diabetes.

Novo Nordisk:Icodec

In addition, no weekly insulin preparation products have been approved for listing in the world, and Novo Nordisk’s Icodec insulin is ahead of schedule. On October 3rd, Novo Nordisk announced the positive results of Icodec’s phase IIIa ONWARDS 5 study, and Novo Nordisk also said that it is expected to apply for regulatory approval of Icodec in the United States, the European Union and China in the first half of 2023.

Cinda Bio:Mazdutide（IBI362）

GLP-1 receptor agonists have grown rapidly in recent years, and have become the non-insulin drugs with the highest market share in the global diabetes market, among which dulaglutide, somaru peptide and liraglutide are outstanding. The multi-target agonist of GLP-1R has also become a hot competitive direction in the research and development of new drugs for diabetes.

Among them, the Mazdutide(IBI362) jointly promoted by Cinda Bio and Lilly is eye-catching. This is a GLP-1R/GCGR dual-target agonist, and its research on type 2 diabetes has reached the phase II clinical stage. On July 19th, Cinda Bio announced that a multi-center, randomized, placebo/dulaglutide-controlled phase II clinical study of IBI362 in type 2 diabetic subjects in China reached the main end point, with remarkable hypoglycemic and weight-loss effects, which can bring comprehensive benefits to patients. On October 4th, Cinda Bio announced the phase III clinical trial of IBI362 for overweight or obesity.

Dongyang Guangyao:Rong ge lie Jing

SGLT-2 target is one of the hot targets in the research and development of new drugs for diabetes in recent years. SGLT-2 inhibitors can block and reduce the reabsorption of glucose by the kidney, thus increasing glucose excretion through urination and lowering blood sugar level.

At present, among the SGLT-2 inhibitors under research, Rongglinide of Dongyangguang has made the fastest progress and has reached the clinical stage III. Tagglinide from Tianjin Institute of Medicine, Vanglinide from Fosun Pharma and Agglinide from Shanghai Alice have also entered the clinic.

A variety of clinical phase III DPP-4 inhibitors

There are many DPP-4 inhibitors in the domestic diabetes drug market, among which DBPR108 from Unacon, Fugliptin from Xinlitai, Shenggliptin from Shengshi Taike, HSK7653 from Haisike and Eugliptin from Yuandong Bio have made rapid progress, and all of them have reached the phase III clinical stage.

Zhengda Tianqing Nanjing Shunxin has laid out two models, TQ-F3083 and TQ05510, and increased the horsepower. The former is in the second clinical stage.

Both of them are DPP-4 inhibitors, and there are differences among different varieties. At present, DPP-4 inhibitors are mostly taken once a day, of which HSK7653 of Haisike Pharmaceutical is taken orally once every two weeks, and Eugliptin of Yuandong Biological and Borgliptin of Baidichang Pharmaceutical need to be taken once a week.

Finally, whether it is insulin or non-insulin diabetes drugs, we all look forward to the early listing to provide more choices for diabetic patients.